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Of all the agriculturally important species studied, fetal male rabbit appeared to be the most sensitive to fumonisin-induced toxicity, on the basis of decreased absolute kidney weight LOEL, 0. Nonetheless, regeneration after either apoptotic or oncotic necrosis is observed at the same doses that cause cancer development.
In some studies, the effects on CYP activity have been shown to be the result of fumonisin-induced alterations in sphingolipid metabolism Merrill et al. Codigos — Google Drive Uncertainty associated with model selection is represented by distributing the frequency of use of each of the alternative models according to a specified weighting criterion i.
This scenario provides a better evaluation of the high end ocvenin the intake distribution of fumonisins; however, the mean intake in this scenario is the same as that in the first. The information is often incomplete: The material retained in liver and kidney is primarily unmetabolized fumonisin B 9as shown in several studies of the persistence in kidney of free sphinganine a biomarker for fumonisin. The uncertainties associated with the predictions made from each model and with model selection are described.
Pulmonary metastases developed in three rats at each dietary concentration. Culture material from F. Of particular concern are the high concentrations found in maize produced and consumed by particular subpopulations, such as subsistence farmers.
Considerable annual variations in contamination have been noted. The diets used in most of the studies summarized in this section differed markedly in nutritional composition.
After commercial dry milling, fumonisins were found in flaking grits, flour, germ, and bran. While removal of the tricarboxylic acid side-chains reduces the ability of fumonisin B 1 to inhibit ceramide synthase, N -acetylation completely abolishes the inhibitory activity Norred et al.
A dramatic increase in the incidence of oesophageal cancer in the Transkei region of Eastern Cape Province, South Africa, was first described by Burrell; Burrell et al. As the proposed mechanisms of action involve alterations in de novo biosynthesis, nutritional factors might be important in toxic end-points.
Results of a collaborative study by 11 laboratories of the repeatability and reproducibility of the method of Shephard et al.
There was coevnin dose-related difference in the survival of rats at weeks.
This observation that a sub-threshold dose can prolong the increase in free sphinganine caused by a higher dose has been confirmed in mice treated by oral gavage Enongene et al.
Analysis of feed intake and degree of fungal contamination indicated a fumonisin B content of 8.
This interaction was clear covenln a mycological analysis of maize harvested during Sydenham et al. In studies on maize Yoshizawa et al. It is produced by strains of F. Therefore, coveni results of studies with these materials corroborate those of studies in which pure fumonisin B 1 was used.